10× More Sensitive Lateral Flow Antibody Pair for Group A Streptococcus Rapid Antigen Detection
The Strep A Antibody Pair is a high-sensitivity capture/detection antibody system for Group A Streptococcus (GAS, Streptococcus pyogenes) rapid antigen testing. With a limit of detection of 2×10² cfu/mL — 10 times lower than the conventional standard of 2×10³ cfu/mL — this antibody pair detects early-stage and low-burden GAS infections that are missed by standard rapid antigen tests.
Validated on 100 clinical and analytical samples with 100% analytical specificity, the pair targets a conserved GAS cell wall antigen expressed across multiple M-protein serotypes. Available as OEM raw material for lateral flow rapid test manufacturers.
Analytical and clinical advantages that make this the right antibody pair for next-generation Strep A rapid tests.
LOD of 2×10² cfu/mL — 10-fold lower than the conventional 2×10³ cfu/mL threshold. Detects early-stage and low-burden GAS infections that would be missed by standard rapid antigen tests.
50 non-GAS and healthy throat swab samples tested; zero false positives. No cross-reactivity with other streptococcal groups (B, C, G) or common respiratory pathogens.
Single-step lateral flow format delivers visual and reader-based results in 5–15 minutes — enabling antibiotic stewardship decisions within the clinical consultation.
Antibody pair targets conserved GAS cell wall antigen epitopes present across multiple M-protein serotypes, ensuring detection regardless of regional strain variation.
Differentiates GAS pharyngitis (requiring antibiotics) from viral pharyngitis (antibiotics contraindicated) — reducing unnecessary antibiotic prescriptions and preventing resistance development.
Capture and detection antibodies available as OEM raw material for licensed rapid test manufacturers. Optimized for nitrocellulose membrane LFA and compatible with visual and reader-based readout.
All data generated using Sekbio anti-GAS monoclonal antibody pair in lateral flow sandwich format.
Gradient dilution series of Strep A antigen (starting from 2×10⁹ cfu/mL) were tested to determine the minimum detectable concentration. The Sekbio Strep A antibody pair achieves a 10-fold lower LOD compared to conventional rapid antigen tests.
| Test Format | Limit of Detection | Comparison |
|---|---|---|
| Conventional Strep A Rapid Test | 2×10³ cfu/mL | Reference standard |
| Sekbio Strep A Antibody Pair | 2×10² cfu/mL | 10× more sensitive |
| LOD determined by gradient dilution of GAS antigen (2×10⁹ cfu/mL stock). Positive/negative threshold defined as visible test line. | ||
One hundred throat swab samples were evaluated: 50 non-GAS/healthy samples and 50 GAS-positive samples. The Sekbio Strep A pair demonstrates complete analytical specificity with zero cross-reactivity.
| Sample Type | n Tested | Expected Result | Observed Result | Concordance |
|---|---|---|---|---|
| Non-GAS / Healthy samples | 50 | Negative | 50 Negative | 100% |
| GAS-positive samples | 50 | Positive | Positive (LOD-dependent) | — |
| Non-GAS samples include specimens from Group B, C, G Streptococcus and common respiratory viral pathogens. Zero false positives observed. | ||||
Group A Streptococcus pharyngitis affects over 600 million people globally per year. Early, low-burden GAS infections — detectable at 2×10² cfu/mL — are clinically important as untreated Strep A can progress to rheumatic fever and glomerulonephritis.
The GAS antibody pair is validated for OEM lateral flow rapid test development and multiple clinical testing contexts.
Rapid point-of-care differentiation of GAS bacterial pharyngitis from viral infection — enabling immediate, guideline-concordant antibiotic prescribing decisions within the consultation.
Children aged 5–15 are the highest-risk group for GAS infection and post-streptococcal complications. Rapid testing enables same-visit treatment and limits transmission in school settings.
5–15 minute result turnaround supports urgent triage in emergency departments, urgent care centers, and community health clinics where culture-based testing is not feasible.
GAS capture and detection antibody pair available for licensed IVD manufacturers developing Strep A rapid antigen tests. ISO 13485-compliant supply chain with consistent lot performance.
Request the full technical datasheet, antibody pair specifications, or discuss OEM supply and rapid test development with our team.