Bone Marker

Bone is the rigid, hard connective tissue that comprises the majority of the skeleton in humans. Bone is a dynamic tissue that undergoes constant remodeling throughout the life span; it turns over at a rate of about 10% a year.

Bone Marker is also known as Bone Resorption Marker, Bone Formation Marker, etc. Bone turnover is balanced with the coupling of bone formation and resorption at various rates leading to continuous remodeling of bone.

Bone markers are used to help evaluate and monitor the rate of bone resorption and construction; the detection of bone turnover markers (BTMs) provides an insight into the dynamics of bone turnover in many metabolic bone disorders.

Bone Marker Products

Parathyroid Hormone (PTH)

Antigen	Application
Recombinant human parathyroid hormone	For immunodiagnostic: ELISA, LFA, CLIA

25-OH Vitamin D

Ferritin(FERR)

Bone Marker Intro

Bone marker detection tests whether there is a disease such as osteoporosis using specific markers. Bone markers can usually be detected in body fluids such as blood and urine and are hormone-like substances.

Clinically detected bone markers can be roughly divided into three categories, as follows:

1. General biochemical markers, including, for example, blood calcium, blood phosphorus, urinary calcium, and urinary phosphorus;

2. Respond to some related hormones that regulate bone metabolisms, such as the typical clinical vitamin D detection and some of its metabolites;

3. Main bone turnover markers are generally divided into two categories; one is called bone formation markers; the other is bone resorption markers. Bone formation markers mainly reflect the activity of osteoblasts and the state of bone formation. Bone resorption markers are often detected clinically to reflect the activity of osteoclasts, such as β-collagen degradation products. Common items of clinical testing include N-terminal osteocalcin and total type I collagen N-terminal extension peptide.

Products

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