Heart-type Fatty Acid Binding Protein (H-FABP)
H-FABP is a low-molecular-weight cytosolic protein involved in the intracellular uptake and buffering of fatty acids in the myocardium.
It is expressed primarily in the heart, but it is not 100% cardio specific since it describes a lesser extent in skeletal muscle, brain, and kidneys. During myocardial injury, the H-FABP level in serum elevated rapidly, making it an ideal marker for myocardial infarction, and it is a useful prognostic marker in patients with the proven acute coronary syndrome. However, renal failure and skeletal muscle disease it has limited diagnostic value for AMI.
SEKBIO provides:
Mouse anti-human FABP mAb.
Recombinant Antigen (H-FABP).
Humanized anti-human FABP mAb. For detection usage.
Heart-type Fatty Acid Binding Protein (H-FABP) Products
| Antibody | Application |
| Mouse Anti-human FABP mAb | For immunodiagnostic: ELISA, LFA, CLIA |
| Recombinant Antigen (H-FABP) | |
| Humanized Anti-human FABP mAb |
| Antigen | Application |
| Recombinant Antigen (H-FABP) | For immunodiagnostic: ELISA, LFA, CLIA |
H-FABP Intro
Heart-type fatty acid-binding protein (hFABP) is a novel small cytoplasmic protein abundant in the heart. It is highly cardiac-specific (i.e., expressed primarily in cardiac tissue) and at low concentrations in tissues other than the heart. Following myocardial ischemic injury, hFABP can be detected in the blood as early as 1-3 hours after the onset of chest pain, peaking at 6-8 hours and plasma levels returning to normal within 24-30 hours. The cardiac fatty acid-binding cytoplasmic protein consists of 132 amino acids with a molecular weight of 15 kDa. The heart-shaped fatty acid-binding protein (hFABP) gene is located on the I chromosome. It is one of the most abundant proteins in the heart. hFABP binds two fatty acid molecules and participates in the transport of fatty acyl-CoA, which is active in the oxidation process to generate energy in mitochondria.
FABP
Fatty acid-binding protein (FABP) exists in various tissues, and the bound protein is albumin, which is most abundant in cardiac muscle and skeletal muscle. FABP is an intracellular fatty acid carrier protein that plays a vital role in the intracellular utilization of fatty acids.
Clinical Value:
1. Diagnosis of AMI: 30min~3h after the onset of AMI, plasma FABP begins to increase and returns to normal within 12h~24h, so FABP is one of the early diagnostic indicators of AMI. Its sensitivity was 78%, significantly higher than Mb and CK-MB. Therefore, FABP is more valuable for early diagnosis of AMI than Mb and CK-MB.
2. Others: Plasma FABP can also be increased in patients with skeletal muscle injury and renal failure.
Reference value: <5ug/L
Indications of FABP detection: ① Early diagnosis of myocardial infarction (reinfarction) ② Monitoring the effect of thrombolytic therapy.
